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Hyaluronic acid (Hyal-Joint)

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By: Sean Moloughney

Editor, Nutraceuticals World

Indication: Knee osteoarthritis (OA)


Source: Nutr J, January 21, 2008;7:3.

Research: In this study, investigators examined the effect of dietary supplementation with a natural extract of chicken combs with a high content of hyaluronic acid (60%) (Hyal-Joint) on pain and quality of life in subjects with knee OA. Twenty subjects 40 years of age and older with knee OA (pain for at least 15 days in the previous month, with symptoms persisting over the past 6 months) participated in this randomized, double-blind, controlled trial. Ten subjects received Hyal-Joint (80 mg/day) and 10 received placebo for 8 weeks. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and quality of life by the Short Form-36 (SF-36v2) were administered at baseline and after 4 and 8 weeks of treatment.

Results: WOMAC pain was similar in both study groups. As compared with baseline, subjects in both groups showed statistically significant im­provements in WOMAC pain, stiffness, physical function subscales and in the aggregate score, but the magnitude of changes was higher in the Hyal-Joint group for WOMAC physical function and total symptoms. At 8 weeks, changes in bodily pain and social functioning were of greater magnitude in subjects given Hyal-Joint. According to researchers, while this pilot clinical trial showed that daily supplementation of Hyal-Joint was useful to enhance several markers of quality of life in adults with knee OA, the results warrant further study in larger sample sizes.

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